| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6019096 | Experimental Neurology | 2012 | 10 Pages |
Abstract
⺠The individual apoE isoform exhibits diverse effect on KA-induced injury. ⺠Overexpression of apoE4 deteriorates KA-induced hippocampal neurodegeneration. ⺠ApoE4 transgenic mice have severe KA-induced seizures and behavioral changes. ⺠ApoE4 transgenic mice show obvious neuronal loss, with glial activation. ⺠KA-induced MHC-II, CD86 and iNOS are elevated in apoE4 transgenic mice.
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Authors
Xing-Mei Zhang, Xi-Jing Mao, Hong-Liang Zhang, Xiang-Yu Zheng, Therese Pham, Abdu Adem, Bengt Winblad, Eilhard Mix, Jie Zhu,