| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6019106 | Experimental Neurology | 2012 | 7 Pages |
Abstract
⺠Thrombosis is proposed as a novel mechanism of delayed cerebral ischemia after SAH. ⺠Microclots form after experimental subarachnoid hemorrhage in mice. ⺠Modified urokinase bound to RBCs safely and effectively reduces microclot burden. ⺠Clazosentan is associated with an increase in microclot burden. ⺠Microclot formation may represent a new target for therapeutic intervention.
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Authors
Jared M. Pisapia, Xiangsheng Xu, Jane Kelly, Jamie Yeung, Geneive Carrion, Huaiyu Tong, Sudha Meghan, Omar M. El-Falaky, M. Sean Grady, Douglas H. Smith, Sergei Zaitsev, Vladimir R. Muzykantov, Michael F. Stiefel, Sherman C. Stein,