| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6019113 | Experimental Neurology | 2012 | 11 Pages |
Abstract
⺠Cobalamin (Cbl) deficiency increases PrPC levels in the SC and CSF of the rat. ⺠Antibodies against the OR-region of a PrPC molecule normalize SC myelin in Cbl-D rats. ⺠Cbl deficiency reduces SC PrPC-mRNA levels, which are increased by Cbl replacement. ⺠EGF and anti-TNF-α-antibodies prevent SC PrPC increase in Cbl-D rats. ⺠Chronic PrPC administration to otherwise normal rats induces SC myelin lesions.
Keywords
intracerebroventricularTNFThermus aquaticusLPTPrPscPrPci.c.v.NGFECLRT-PCRHRPEGFGFAPPBSPTFEABSSALcycle thresholdantibodiesenzyme-linked immunosorbent assaysstandard deviationimmunoglobulin Recombinantenhanced chemiluminescenceTaqanalysis of varianceANOVAELISAtumor necrosis factor-αCNSforwardSalinecentral nervous systemAnti-TNF-αSpinal cordepidermal growth factornerve growth factortumor necrosis factorThoraciclumbarLaparotomyMonthCerebrospinal fluidCSFTotal gastrectomyreversereal-time polymerase chain reactionGlial fibrillary acidic proteinProteinase KpolytetrafluoroethylenecobalaminCblCobalamin deficiencyCervical
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Authors
Giuseppe Scalabrino, Daniela Veber, Elena Mutti, Alberto Calligaro, Silvano Milani, Giovanni Tredici,