| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6019136 | Experimental Neurology | 2012 | 9 Pages |
Abstract
⺠Chronic convection enhanced delivery of siRNA targeting Huntingtin in primate brain. ⺠Widespread drug distribution results in Huntingtin lowering throughout striatum. ⺠Empirical model of data enables scaling of siRNA delivery. ⺠Potential as key disease-modifying therapeutic approach for Huntington's disease.
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Authors
David K. Stiles, Zhiming Zhang, Pei Ge, Brian Nelson, Richard Grondin, Yi Ai, Peter Hardy, Peter T. Nelson, Andrei P. Guzaev, Mark T. Butt, Klaus Charisse, Verbena Kosovrasti, Lubomir Tchangov, Michael Meys, Martin Maier, Lubomir Nechev,