Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6019459 | Experimental Neurology | 2008 | 10 Pages |
Abstract
The findings suggest that a less organised/compact axoskeleton or impaired axonal transport may represent an early sign of axonal pathology within the normal appearing white matter in MS. Subsequently a proportional increase of dephosphorylated NfH, aberrant phosphorylation and/or aggregation may occur whilst the protein is transported through the white matter towards the MS plaque, where hyperphosphorylated NfH dominates.
Keywords
NAWMbrain-specific proteinsNeurofilament heavy chainSAPKNFLEDSSBSPNFHIQRCTRLSALAxonal injuryALPAlkaline phosphataseELISArelapsing remittingCNSNeurofilament light chaincentral nervous systemGray matterwhite matterNormal-appearing white matterinterquartile rangeExpanded Disability Status ScaleMultiple sclerosisElectron microscopyneurofilamentprimary progressivesecondary progressivecontrol group
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Authors
Axel Petzold, Djordje Gveric, Mike Groves, Klaus Schmierer, Donna Grant, Miles Chapman, Geoffrey Keir, Louise Cuzner, Edward J. Thompson,