| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021267 | Neurobiology of Disease | 2016 | 41 Pages |
Abstract
The insets show key results of the present study: Progranulin overexpression in sensory neurons reduced nociceptive behavior after nerve injury, reduced protein aggregates in dorsal root ganglia (DRGs) and improved healing of the nerve stump. Progranulin colocalized with ATG4b and 12, which were yeast-2-hybrid preys, and facilitated the autophagic flux, which was impaired after nerve injury.
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Authors
Christine Altmann, Stefanie Hardt, Caroline Fischer, Juliana Heidler, Hee-Young Lim, Annett Häussler, Boris Albuquerque, Béla Zimmer, Christine Möser, Christian Behrends, Frank Koentgen, Ilka Wittig, Mirko H.H. Schmidt, Albrecht M. Clement,