Article ID Journal Published Year Pages File Type
6021370 Neurobiology of Disease 2016 16 Pages PDF
Abstract
In this model, chronic exposure to low-doses of rotenone was not sufficient to alter mitochondrial integrity and ATP production, but profoundly impaired the expression of long-term plasticity at corticostriatal synapses in PINK1 heterozygous knockout mice, suggesting that disruption of synaptic plasticity may represent an early feature of a pre-manifesting state of the disease, and a potential tool to test novel neuroprotective agents.
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Life Sciences Neuroscience Neurology
Authors
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