Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021442 | Neurobiology of Disease | 2016 | 47 Pages |
Abstract
sALS is associated with tissue-specific DHA-dependent synthetic machinery alteration. Furthermore, excitotoxicity sinergizes with oxidative stress to increase DHA levels, which could act as a response over stress, involving the expression of DHA synthetic enzymes. Later on, this allostatic overload could exacerbate cell stress by contributing to TDP-43 aggregation. This, at its turn, could blunt this protective response, overall leading to DHA depletion and neuronal dysfunction.
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Authors
Daniel Cacabelos, Victòria Ayala, Ana Belén Granado-Serrano, Mariona Jové, Pascual Torres, Jordi Boada, Rosanna Cabré, Omar RamÃrez-Núñez, Hugo Gonzalo, Aranzazu Soler-Cantero, José Carlos Enrique Serrano, Maria Josep Bellmunt, MarÃa Paz Romero,