Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

Article ID	Journal	Published Year	Pages	File Type
6021495	Neurobiology of Disease	2015	11 Pages	PDF

Abstract

Pyruvate can be therefore a valuable, safe, and affordable pharmacological tool to be associated with classical anti-AÎ² and tau drugs to counteract the development and progression of AD-related cognitive deficits and neuronal loss.

Keywords

TBARS NMDAR i.p MWM NFTs N-methyl-d-aspartate NMDA BN-PAGE Aβ 3xTg-AD mice DTDP 2,2′-dithiodipyridine GC-MS HET P-Tau ROS [Ca2 +]i Amyloid amyloid-β blue-native polyacrylamide gel electrophoresis Alzheimer's disease Hyperphosphorylated tau intraperitoneal injection Oxidative stress Tau Brain metabolism Zinc lactate dehydrogenase LDH Morris water maze neurofibrillary tangles Thiobarbituric reactive substances Pyruvate gas chromatography coupled to mass spectrometry Reactive oxygen species N-methyl-d-aspartate receptor

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Pyruvate prevents the development of age-dependent cognitive deficits in a mouse model of Alzheimer's disease without reducing amyloid and tau pathology

Authors

Elisa Isopi, Alberto Granzotto, Carlo Corona, Manuela Bomba, Domenico Ciavardelli, Michele Curcio, Lorella M.T. Canzoniero, Riccardo Navarra, Rossano Lattanzio, Mauro Piantelli, Stefano L. Sensi,