Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021495 | Neurobiology of Disease | 2015 | 11 Pages |
Abstract
Pyruvate can be therefore a valuable, safe, and affordable pharmacological tool to be associated with classical anti-Aβ and tau drugs to counteract the development and progression of AD-related cognitive deficits and neuronal loss.
Keywords
TBARSNMDARi.pMWMNFTsN-methyl-d-aspartateNMDABN-PAGEAβ3xTg-AD miceDTDP2,2′-dithiodipyridineGC-MSHETP-TauROS[Ca2 +]iAmyloidamyloid-βblue-native polyacrylamide gel electrophoresisAlzheimer's diseaseHyperphosphorylated tauintraperitoneal injectionOxidative stressTauBrain metabolismZinclactate dehydrogenaseLDHMorris water mazeneurofibrillary tanglesThiobarbituric reactive substancesPyruvategas chromatography coupled to mass spectrometryReactive oxygen speciesN-methyl-d-aspartate receptor
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Authors
Elisa Isopi, Alberto Granzotto, Carlo Corona, Manuela Bomba, Domenico Ciavardelli, Michele Curcio, Lorella M.T. Canzoniero, Riccardo Navarra, Rossano Lattanzio, Mauro Piantelli, Stefano L. Sensi,