Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021503 | Neurobiology of Disease | 2016 | 10 Pages |
Abstract
We identified multiple cell types in the origin of NBIA disorders. We also found unforeseen links between NBIA networks and iron-related processes, and demonstrate convergent pathways connecting NBIAs and phenotypically overlapping diseases. Our results are of further relevance for these diseases by providing candidates for new causative genes and possible points for therapeutic intervention.
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Authors
Conceição Bettencourt, Paola Forabosco, Sarah Wiethoff, Moones Heidari, Daniel M. Johnstone, Juan A. BotÃa, Joanna F. Collingwood, John Hardy, for the UK Brain Expression Consortium (UKBEC) for the UK Brain Expression Consortium (UKBEC),