| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021534 | Neurobiology of Disease | 2016 | 10 Pages |
Abstract
Recombinant Slit2 improved outcomes by reducing neuroinflammation after SBI, possibly by decreasing peripheral immune cell infiltration to the perisurgical site through Robo1-srGAP1 mediated inhibition of Cdc42 activity. These results suggest that Slit2 may be beneficial to reduce SBI-induced neuroinflammation.
Keywords
ICVp21 binding domainp21 activated kinasePBDCDC42CD45PAKintracerebroventricularSlit2NeuNSbiGFAPPBSMPORobo1Surgical brain injuryenzyme linked immunosorbent assayBrain edemaNeuroinflammationELISAcluster of differentiation 45Phosphate buffered salinemyeloperoxidaseneuronal nucleiGlial fibrillary acidic protein
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Authors
Prativa Sherchan, Lei Huang, Yuechun Wang, Onat Akyol, Jiping Tang, John H. Zhang,