| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021592 | Neurobiology of Disease | 2015 | 11 Pages |
Abstract
Summary of the graphical abstract for the Role of Rhes in Huntington's disease (HD). (A) Rhes deleted N171-82Q transgenic (Rhes KO/N171-82Q) mice are protected from HD-related behavioral and anatomical deficits, whereas Rhes overexpression in the cerebellum of N171-82Q mice potentiates HD-related deficit and induces ataxia-like phenotype. (B) Hdh150Q/150Q knock-in HD mice develops late onset, but reintroducing Rhes into Rhes deleted Hdh150Q/150Q (Rhes KO/Hdh150Q/150Q) mice striatum elicits rapid HD onset, such as rotarod defects.325
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Authors
Supriya Swarnkar, Youjun Chen, William M. Pryor, Neelam Shahani, Damon T. Page, Srinivasa Subramaniam,