Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021666 | Neurobiology of Disease | 2015 | 12 Pages |
Abstract
Our experimental results support the hypothesis that there are deleterious interactions between chronic cerebral hypoperfusion and T2DM. That is, metabolic diseases such as diabetes may exacerbate cognitive impairment in a rat model of vascular dementia. We also suggest that surprisingly, the phosphodiesterase III inhibitor, cilostazol may be useful for the treatment of cognitive impairment in diabetes mellitus-induced dementia. In conclusion, diabetes can aggravate cognitive dysfunction in vascular dementia, and PDE-3 inhibitors, such as cilostazol, may form the basis of a novel therapeutic strategy for diabetes-associated cognitive impairment or vascular dementia.
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Neurology
Authors
Kyoung Ja Kwon, Eun Joo Lee, Min Kyeong Kim, Soo Young Kim, Jung Nam Kim, Jin Ok Kim, Hee-Jin Kim, Hahn Young Kim, Jung-Soo Han, Chan Young Shin, Seol-Heui Han,