| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021681 | Neurobiology of Disease | 2015 | 13 Pages |
Abstract
Our studies thus confirm ROCK2 as a promising therapeutic target in models of PD and demonstrate that neuron-specific inhibition of ROCK2 promotes survival of lesioned dopaminergic neurons.
Keywords
6-OHDAdopaminergic degenerationLIMKLimk1ROCK2PMNERK1IBA1IPL1-methyl-4-phenylpyridiniumAAVDOPACDAPIERKBcl-2shRNASTAT3CTLGFAPeGFP6-Hydroxydopamine3,4-dihydroxyphenylacetic acid4′,6-diamidino-2-phenylindoleMAPKMPP+Adeno-associated viral vectorParkinson's diseasesubstantia nigratyrosine hydroxylaseCNSipsilateralDIVday in vitrocentral nervous systemphosphatase and tensin homolog deleted on chromosome tenB-cell lymphoma 2signal transducer and activator of transcription 3ionized calcium binding adapter molecule 1homovanillic acidGlial fibrillary acidic proteinenhanced green fluorescent proteinmitogen-activated protein kinaseRho-associated protein kinaseHVAPtenhigh performance liquid chromatographyHPLCcontralateralextracellular-signal-regulated kinaseRock
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Authors
Kim-Ann Saal, Jan C. Koch, Lars Tatenhorst, Ãva M. SzegÅ, Vinicius Toledo Ribas, Uwe Michel, Mathias Bähr, Lars Tönges, Paul Lingor,