| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6021893 | Neurobiology of Disease | 2014 | 11 Pages |
Abstract
The high directional coupling from somatosensory cortex to the thalamus at SWD onset is in good agreement with the idea of a cortical epileptic focus that initiates and entrains other brain structures into seizure activity. The decrease of cortex to rRTN coupling as well as the increased coupling from cRTN to rRTN preceding SWD termination demonstrates that SWD termination is a gradual process that involves both cortico-thalamic as well as intrathalamic processes. The rostral RTN seems to be an important resonator for SWD and relevant for maintenance, while the cRTN might inhibit this oscillation. The somatosensory cortex seems to attempt to reinitiate SWD following its offset via its strong coupling to the posterior thalamus.
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Authors
Annika Lüttjohann, Jan-Mathijs Schoffelen, Gilles van Luijtelaar,