Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6021935 | Neurobiology of Disease | 2014 | 14 Pages |
Abstract
We present the first evidence of a male-specific vulnerability to stress impacting on the development of short-term memory deficits in HD. More generally, we found that female mice were protected from the detrimental effects of CORT treatment on a variety of hippocampus-based measures. Hippocampal plasticity and memory in HD may be more susceptible to the impacts of stress in a sex-dependent manner. We propose clinical investigations of stress as a key environmental modifier of HD symptom onset.
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Authors
Christina Mo, Terence Y. Pang, Mark I. Ransome, Rachel A. Hill, Thibault Renoir, Anthony J. Hannan,