| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022093 | Neurobiology of Disease | 2014 | 12 Pages |
Abstract
Altogether these results indicate that ET-1 exerts a toxic effect on cultured MNs through mechanisms mediated by reactive astrocytes and suggest that ET-1 may contribute to MN degeneration in ALS. Thus, a treatment aimed at lowering ET-1 levels or antagonizing its effect might be envisaged as a potential therapeutic strategy to slow down MN degeneration in this devastating disease.
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Authors
Eugenia Ranno, Simona D'Antoni, Michela Spatuzza, Antonio Berretta, Floriana Laureanti, Carmela M. Bonaccorso, Rosalia Pellitteri, Patrizia Longone, Alida Spalloni, Anand M. Iyer, Eleonora Aronica, Maria Vincenza Catania,