| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022307 | Neurobiology of Disease | 2013 | 11 Pages |
Abstract
⺠Polymorphisms in complement CR1 gene linked to increased risk of Alzheimer's disease. ⺠Microglial CR1 activation linked to phagocytosis and Aβ clearance. ⺠Activated microglia show enhanced CR1 expression and microglial CR1 stimulation is detrimental to neurons. ⺠Block of CR1 decreased Aβ phagocytosis, but enhanced dextran bead uptake.
Keywords
AβiNOSNGSRAGEAPPPVDFCR1MCBPFAD-MEMECLLPSreceptor for advanced glycation end productTNFαPBSIL-1βAβ1–42Dulbecco's modified Eagle MediumCGCPMAROSapoApocyninEthacrynic acidSDS-PAGEInterleukin-1 betaLoadamyloid betaenhanced chemiluminescenceAlzheimer's diseaseLate-onset Alzheimer's diseaseELISAEnzyme-linked immunosorbent assaytumour necrosis factor-alphapolyvinylidene difluoridedihydroethidiumDIVdays in vitronormal goat serumcerebellar granule cellsinducible nitric oxide synthaseSuperoxideCytokinePhagocytosisphorbol myristate acetatePhosphate buffered salinelipopolysaccharideGenome-wide association studyGWASMonochlorobimaneMicrogliaNitric oxideDHEparaformaldehydeamyloid precursor proteinPropidium iodideReactive oxygen speciescomplement receptor 1
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Helen Crehan, John Hardy, Jennifer Pocock,