Isoflurane postconditioning reduces ischemia-induced nuclear factor-ÎºB activation and interleukin 1Î² production to provide neuroprotection in rats and mice

Article ID	Journal	Published Year	Pages	File Type
6022316	Neurobiology of Disease	2013	9 Pages	PDF

Abstract

âº Isoflurane postconditioning improves long-term neurological outcome after focal brain ischemia in rats. âº Isoflurane postconditioning reduces inflammatory cytokine production in the ischemic brain tissues. âº Isoflurane postconditioning-induced neuroprotection may be mediated by reducing inflammatory cytokines.

Keywords

NF-κB IL-1β MCAO middle cerebral arterial occlusion postconditioning FR1 SpO2 PDTC pulse oximeter oxygen saturation Isoflurane interleukin 1β TUNEL pyrrolidine dithiocarbamate Nuclear transcription factor-κB nuclear factor-κB Neuroprotection