| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022322 | Neurobiology of Disease | 2013 | 16 Pages |
Abstract
⺠RNF11 modulates susceptibility to 6-OHDA toxicity through NF-κB signaling. ⺠Protection against 6-OHDA toxicity involves antioxidants and anti-apoptotic factors. ⺠Neuronal RNF11 acts as a negative regulator of NF-κB signaling in vivo. ⺠RNF11 expression is reduced in PD cortical and nigral tissues.
Keywords
AAVventral mesencephalicRNF11Tax1BP1TNFRGS10GSSCD200dorsoventralIKKSOD1DLBVTANurr1GUSBqRT-PCRNF-κB6-OHDA6-HydroxydopamineshRNAGAPDHBDNFE3 ligaseIκB kinasesmall hairpin RNASNpcAntioxidantsHuman tissuebeta-glucuronidaseAlzheimer's diseaseParkinson's diseaseanalysis of varianceANOVAsubstantia nigraNeurodegenerationtyrosine hydroxylasestandard error of the meanmediolateralDLB, Dementia with Lewy bodiessuperoxide dismutase 1Brain-derived neurotrophic factortumor necrosis factornuclear factor κBSEMventral tegmental areaquantitative real-time PCRAdeno-associated virusanteroposteriorglutathione synthetaseglyceraldehyde 3-phosphate dehydrogenase
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Elaine L. Pranski, Nirjari V. Dalal, Carson Van Sanford, Jeremy H. Herskowitz, Marla Gearing, Carlos Lazo, Gary W. Miller, James J. Lah, Allan I. Levey, Ranjita S. Betarbet,