| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022326 | Neurobiology of Disease | 2013 | 11 Pages |
Abstract
⺠Nav1.1 (SCN1A) deficits are linked to Dravet syndrome and other cognitive disorders. ⺠RNA interference was used to knockdown Nav1.1 expression in the basal forebrain region. ⺠Nav1.1 knockdown impaired spatial cognition in the absence of seizures. ⺠Impaired spatial performance was associated with a dysregulation of theta frequency. ⺠Nav1.1 deficits may impair network oscillations and cognition in human disorders.
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Authors
Alex C. Bender, Heather Natola, Christian Ndong, Gregory L. Holmes, Rod C. Scott, Pierre-Pascal Lenck-Santini,