| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022349 | Neurobiology of Disease | 2013 | 8 Pages |
Abstract
⺠The expression of several miRNAs is altered early in the pathogenesis of SCA1. ⺠miR-150 expression is increased in the Purkinje cells of SCA1 transgenic mice. ⺠miR-150 targets Rgs8 and Vegfa in cultured neuronal cells, two mRNAs down-regulated in SCA1. ⺠Reducing mutant ataxin-1 levels increases miR-150 and Vegfa.
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Authors
Edgardo Rodriguez-Lebron, Gumei Liu, Megan Keiser, Mark A. Behlke, Beverly L. Davidson,