| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022352 | Neurobiology of Disease | 2013 | 11 Pages |
Abstract
⺠Ethanol treatment at P7 induces apoptotic pattern described for binge model of FASD. ⺠Results in enhanced G9a expression and increased H3K9me2 and H3K27me2/H3 ratios ⺠Leads to H3K9me2 specific degradation of H3 proteins by activated caspase-3 ⺠Blockade of G9a before ethanol exposure rescues H3K9me2, H3K27me2 and H3 levels. ⺠Bix 01294 prevents neurodegeneration and may have a clinical potential against FASD.
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Authors
Shivakumar Subbanna, Madhu Shivakumar, Nagavedi S. Umapathy, Mariko Saito, Panaiyur S. Mohan, Asok Kumar, Ralph A. Nixon, Alexander D. Verin, Delphine Psychoyos, Balapal S. Basavarajappa,