| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022368 | Neurobiology of Disease | 2013 | 10 Pages |
Abstract
⺠The role of stathmin in SMA is addressed by crossing SMA mice into stathmin knockout background. ⺠Heterozygous stathmin knockout improves motor performance and muscle pathology. ⺠The improvements observed in SMA mice are likely due to the recovery of microtubules in axons. ⺠Stathmin knockout cannot prevent the death of severe type SMA mice. ⺠Stathmin involves in the axonal defects in SMA, but is not associated with the death of SMA mice.
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Authors
Hsin-Lan Wen, Chen-Hung Ting, Huei-Chun Liu, Hung Li, Sue Lin-Chao,