| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022369 | Neurobiology of Disease | 2013 | 13 Pages |
Abstract
⺠PDE10A increases in the striatal projection neurons of R6/2 mice. Such accumulation occurs in the perikarya. ⺠PDE10 levels decrease in the whole striatum of R6/2 animals as observed in the densitometry studies. ⺠Accumulation of PDE10A might cause massive hydrolization of cyclic nucleotides damaging the cell. ⺠PDE10 decrease in the whole striatum is possibly due to its sequestration in the perikarya of projection neurons. ⺠PDE10A inhibitor TP10 lowers PDE10A levels efficiently in the medium spiny neurons perikarya. ⺠Cholinergic neurons, resistant to HD, contain moderate amounts of PDE10A, which do not change with TP10 treatment. ⺠PDE10A is present in the other subsets of striatal interneurons, where it is localized in the neuronal nuclei.
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Authors
Alessandro Leuti, Daunia Laurenti, Carmela Giampà , Elena Montagna, Clemente Dato, Serenella Anzilotti, Mariarosa A.B. Melone, Giorgio Bernardi, Francesca R. Fusco,