Article ID Journal Published Year Pages File Type
6022370 Neurobiology of Disease 2013 11 Pages PDF
Abstract
► Normalization of Dyrk1A levels was achieved in trisomic mice using viral particles. ► Dyrk1A normalization attenuates hippocampal phenotype in adult trisomic mice. ► Dyrk1A is a potential target in adult trisomic mouse models of Down syndrome.
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Life Sciences Neuroscience Neurology
Preview
Normalization of Dyrk1A expression by AAV2/1-shDyrk1A attenuates hippocampal-dependent defects in the Ts65Dn mouse model of Down syndrome
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