| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022383 | Neurobiology of Disease | 2013 | 8 Pages |
Abstract
⺠Hippocampal LTP is impaired during the acute clinical phase of EAE, a model of direct CNS inflammation. ⺠Hippocampal LTP is also impaired in mice with systemic, peripherally-triggered inflammation (SI). ⺠Both during EAE and SI, hippocampal microglia is activated. ⺠Exclusively in EAE, but not during SI, the levels of the NR2B subunit of the NMDA receptor are reduced in the hippocampus. ⺠Exclusively in EAE, but not during SI, the levels of interleukin-1β are increased in the hippocampus.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Massimiliano Di Filippo, Davide Chiasserini, Fabrizio Gardoni, Barbara Viviani, Alessandro Tozzi, Carmela Giampà , Cinzia Costa, Michela Tantucci, Elisa Zianni, Mariaserena Boraso, Sabrina Siliquini, Antonio de Iure, Veronica Ghiglieri, Elisa Colcelli,