| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022400 | Neurobiology of Disease | 2013 | 11 Pages |
Abstract
⺠ALS patients had a reduction in skeletal muscle PGC-1α mRNA and protein as well as ERRα and Mfn2 mRNA. ⺠ALS patients had reduced skeletal muscle citrate synthase and cytochrome c oxidase activities. ⺠ALS patients had an increase in skeletal muscle miR-23a, -29b, -206 and â455. ⺠Reporter assays confirmed that miR-23a repressed PGC-1α translation in a 3â² UTR dependent manner. ⺠Transgenic mice over expressing miR-23a had reduced PGC-1α, cytochome-b and COXIV protein levels.
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Authors
Aaron P. Russell, Shogo Wada, Lodovica Vergani, M. Benjamin Hock, Séverine Lamon, Bertrand Léger, Takashi Ushida, Romain Cartoni, Glenn D. Wadley, Peter Hespel, Anastasia Kralli, Gianni Soraru, Corrado Angelini, Takayuki Akimoto,