Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022408 | Neurobiology of Disease | 2013 | 10 Pages |
Abstract
⺠We examined effects of CCR5 deficiency on the dopamine neuron via MPTP animal model. ⺠CCR5 deletion led to loss of nigral dopamine neurons and microglial activation. ⺠Monoamine oxidase B was elevated in astrocytes of CCR5 null mice. ⺠MPTP neurotoxicity was more severe in CCR5 knockout mice. ⺠We report importance of cross talk between glia and neurons via CCR5.
Keywords
CCRC–C chemokine receptor 5MPP +MAODOPACMPTPDATMIPGFAP1-methyl-4-phenyl-1,2,3,6-tetrahydropyridineMAPKAstrocyteStriatumDopamine transporterParkinson's diseasesubstantia nigratyrosine hydroxylaseDopaminemonoamine oxidaseknockoutwild typehomovanillic acidGlial fibrillary acidic proteinmacrophage inflammatory proteinmitogen-activated protein kinaseHVA
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Authors
Dong-Young Choi, Myung Koo Lee, Jin Tae Hong,