Article ID Journal Published Year Pages File Type
6022408 Neurobiology of Disease 2013 10 Pages PDF
Abstract
► We examined effects of CCR5 deficiency on the dopamine neuron via MPTP animal model. ► CCR5 deletion led to loss of nigral dopamine neurons and microglial activation. ► Monoamine oxidase B was elevated in astrocytes of CCR5 null mice. ► MPTP neurotoxicity was more severe in CCR5 knockout mice. ► We report importance of cross talk between glia and neurons via CCR5.
Related Topics
Life Sciences Neuroscience Neurology
Authors
, , ,