Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

Article ID	Journal	Published Year	Pages	File Type
6022411	Neurobiology of Disease	2013	13 Pages	PDF

Abstract

âº Derangements of RelA and histone acetylation occur in harmful ischemia. âº The acetylation derangements are targets of HDAC inhibitor MS-275 and resveratrol. âº MS-275 increases total RelA acetylation, resveratrol deacetylates RelA at Lys310. âº Synergistic low doses of MS-275 and resveratrol reduce brain injury in MCAO mice. âº The treatment is effective even when administered 7Â h after the stroke onset.

Keywords

NF-κB sirtuin 1 CBP MCAO OGD HDAC Sirt1 middle cerebral artery occlusion intraperitoneal DIV days in vitro nuclear factor kappa B lactate dehydrogenase LDH HDAC inhibitors CSF Cerebrospinal fluid Oxygen glucose deprivation Histone acetyltransferase histone deacetylase HAT