| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022412 | Neurobiology of Disease | 2013 | 9 Pages |
Abstract
⺠Atg8 homologues; LC3, GABARAPs and GATE-16, are highly involved in autophagosomal formation. ⺠We investigated whether Atg8 homologues were altered in multiple system atrophy (MSA). ⺠Expression levels of GABARAPs and GATE-16 were decreased in MSA. ⺠Pathologically glial cytoplasmic inclusions were positive for LC3. ⺠Autophagic maturation can be impaired through the repressed levels of Atg8 homologues in MSA.
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Authors
Kunikazu Tanji, Saori Odagiri, Atsushi Maruyama, Fumiaki Mori, Akiyoshi Kakita, Hitoshi Takahashi, Koichi Wakabayashi,