| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022415 | Neurobiology of Disease | 2013 | 10 Pages |
Abstract
⺠Nav1.1 is expressed in most PV interneurons in the neocortex and hippocampus. ⺠Nav1.1 is expressed in 5-13% of excitatory cells in neocortex and hippocampus. ⺠Preferential inactivation of one Scn1a allele in PV interneurons reduces seizure thresholds. ⺠Inactivation of one Scn1a allele in excitatory cells does not alter seizure thresholds. ⺠Preferential inactivation of one Scn1a allele in PV interneurons results in spontaneous seizures.
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Authors
Stacey B. Dutton, Christopher D. Makinson, Ligia A. Papale, Anupama Shankar, Bindu Balakrishnan, Kazu Nakazawa, Andrew Escayg,