Article ID Journal Published Year Pages File Type
6022423 Neurobiology of Disease 2012 11 Pages PDF
Abstract
► Chronic l-DOPA increases striatal TH neurons in a dose-dependent way in parkinsonian mice. ► l-DOPA induction of TH neurons in lesioned striatum requires dopamine D1 receptors and ERK activation. ► Tight correlation between striatal TH-ir neurons, recovery of DA overflow and contralateral forelimb use. ► Induction of striatal TH neurons by l-DOPA is independent of Pixt3 expression. ► Olfactory bulb grafts also induce TH neurons in denervated striatum.
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