Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022423 | Neurobiology of Disease | 2012 | 11 Pages |
Abstract
⺠Chronic l-DOPA increases striatal TH neurons in a dose-dependent way in parkinsonian mice. ⺠l-DOPA induction of TH neurons in lesioned striatum requires dopamine D1 receptors and ERK activation. ⺠Tight correlation between striatal TH-ir neurons, recovery of DA overflow and contralateral forelimb use. ⺠Induction of striatal TH neurons by l-DOPA is independent of Pixt3 expression. ⺠Olfactory bulb grafts also induce TH neurons in denervated striatum.
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Authors
Isabel Espadas, Sanja Darmopil, Eva Vergaño-Vera, Oskar Ortiz, Idaira Oliva, Carlos Vicario-Abejón, Eduardo D. MartÃn, Rosario Moratalla,