Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022424 | Neurobiology of Disease | 2012 | 8 Pages |
Abstract
⺠NP03, a novel formulation, allows delivery of significantly lower yet pharmacologically active amounts of lithium. ⺠NP03 ameliorates motor dysfunction and neuropathology in YAC128 HD mice. ⺠NP03 corrects multiple HD-related molecular deficits in YAC128 HD mice. ⺠NP03 is safe with no toxicity associated with long-term use in YAC128 HD mice. ⺠NP03 is neuroprotective in the YAC128 HD mice and a promising approach to treatment of HD.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Mahmoud A. Pouladi, Elsa Brillaud, Yuanyun Xie, Paola Conforti, Rona K. Graham, Dagmar E. Ehrnhoefer, Sonia Franciosi, Weining Zhang, Patrick Poucheret, Elsa Compte, Jean-Claude Maurel, Chiara Zuccato, Elena Cattaneo, Christian Néri, Michael R. Hayden,