| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022425 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠We tested the neuroprotective effects of genetic overexpression of GluN3A subunits. ⺠GluN3A protects vulnerable striatal medium-spiny neurons from excitotoxic damage. ⺠GluN3A-containing NMDARs in striatal neurons incorporate GluN1 and GluN2B subunits. ⺠GluN3A-containing NMDARs are targeted to synaptic and extrasynaptic compartments. ⺠GluN3A overexpression suppresses toxic calpain activation.
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Authors
Rebeca MartÃnez-Turrillas, Elena Puerta, Dhrubajyoti Chowdhury, Sonia Marco, Masahiko Watanabe, Norberto Aguirre, Isabel Pérez-Otaño,