| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022429 | Neurobiology of Disease | 2012 | 12 Pages |
Abstract
⺠Experimental epilepsy reduces the complexity of interneuron firing patterns. ⺠There is a loss of interneurons able to fire at high frequency. ⺠The loss is not due to cell death but instead is due to interneuron plasticity. ⺠The phenotype change is due to the up-regulation of a potassium current identified as the Kv1.6 subtype. ⺠Our data suggest a new mechanism by which epileptic seizures are generated.
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Authors
Cezar Gavrilovici, Emily Pollock, Michelle Everest, Michael O. Poulter,