| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022437 | Neurobiology of Disease | 2012 | 12 Pages |
Abstract
⺠The effect of BoNT-A on TRPV1 expression was investigated in the trigeminal system. ⺠BoNT-A decreased TRPV1 expression in the trigeminal ganglion. ⺠BoNT-A inhibited TRPV1 trafficking to the plasma membrane. ⺠Cytoplasmic TRPV1 was predisposed to proteasome-mediated proteolysis. ⺠These data explain how BoNT-A relieves TRPV1-mediated pain.
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Authors
Toshihiko Shimizu, Mamoru Shibata, Haruki Toriumi, Tatsuo Iwashita, Megumi Funakubo, Hitoshi Sato, Toshiya Kuroi, Taeko Ebine, Kenzo Koizumi, Norihiro Suzuki,