| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022443 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠We examined spontaneous cortical activity in R6/1, a model of Huntington's disease. ⺠The segregation between active and slow-wave states is altered in R6/1 mice. ⺠Slow wave sleep was invaded by “ectopic” theta episodes and interictal spikes in R6/1. ⺠Ectopic theta was reversed by the cholinergic antagonist atropine. ⺠Altered brain states and cholinergic systems might relate to cognitive decline in HD.
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Authors
Michele Pignatelli, Fanny Lebreton, Yoon H. Cho, Xavier Leinekugel,