| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022468 | Neurobiology of Disease | 2012 | 12 Pages |
Abstract
⺠A verified LRRK2 antibody detects widespread expression in mouse brain by IHC. ⺠LRRK2 expression is highest in striatum and mainly expressed in medium spiny neurons. ⺠LRRK2 expression is enriched in striatal patches termed striosomes. ⺠Loss of LRRK2 expression does not affect striatal compartmentalization. ⺠Striatal compartmentalization in LRRK2-R1441G transgenic mice is disturbed.
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Authors
Wim Mandemakers, An Snellinx, Michael J. O'Neill, Bart de Strooper,