Mitochondria, oligodendrocytes and inflammation in bipolar disorder: Evidence from transcriptome studies points to intriguing parallels with multiple sclerosis

Article ID	Journal	Published Year	Pages	File Type
6022477	Neurobiology of Disease	2012	11 Pages	PDF

Abstract

âº Literature review of gene expression studies of bipolar disorder. âº Comparison to data from schizophrenia and major depressive disorder. âº All three disorders show major overlaps in their transcriptome profiles. âº Genes involved in energy metabolism, inflammation and myelination are highlighted. âº Multiple sclerosis models could be of interest for psychiatry research.

Keywords

Microarrays OXPHOS BPD MDD Major depressive disorder mood disorders bipolar disorder Schizophrenia inflammation Transcriptome Oxidative phosphorylation white matter Multiple sclerosis Mitochondria Myelin TCA cycle tricarboxylic acid cycle oligodendrocytes