| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022483 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠Microarrays and qPCR assessed CA1 neurons and regional hippocampal dissections. ⺠Downregulation of select genes was seen in AD versus CTR for CA1 pyramidal neurons. ⺠Hippocampal dissections showed upregulation of markers indicating admixed cell types. ⺠CA1 neuron and regional hippocampal dissections in mice paralleled human findings. ⺠qPCR validated microarray findings in AD versus CTR and in wild type mice.
Keywords
CTRDHSSDSqPCRAPPNFTsGluRLCMCBFAβGAPDHESTsSSPEcycle thresholdApoeapolipoprotein EMolecular fingerprintmild cognitive impairmentAlzheimer's diseaseSingle cell analysisanalysis of varianceANOVAMicroarraysodium dodecyl sulfateDown syndromecytSynPMIPostmortem intervallaser capture microdissectionPostmortem human brainneurofibrillary tanglesMCIHippocampusamyloid-β precursor proteinExpression profilingamyloid-β peptidecholinergic basal forebrainmouse chromosome 16glyceraldehyde-3 phosphate dehydrogenaseGlia
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
Stephen D. Ginsberg, Melissa J. Alldred, Shaoli Che,