Nerve growth factor/p38 signaling increases intraepidermal nerve fiber densities in painful neuropathy of type 2 diabetes

Article ID	Journal	Published Year	Pages	File Type
6022511	Neurobiology of Disease	2012	8 Pages	PDF

Abstract

âº We found increased peptidergic nerve fiber densities in diabetic skin. âº Anti-nerve growth factor inhibited the increased peptidergic nerve fiber densities. âº SB203580 inhibited the upregulation of peptidergic nerve fiber densities. âº Nerve growth factor/p38 signaling mediates increased nerve fibers in diabetic skin.

Keywords

IGT PDN IENFD PGP NGF IFG CGRP STZ PBS DMSO Mechanical allodynia impaired glucose tolerance Impaired fasting glucose streptozotocin Intraepidermal nerve fibers Trk Type 2 diabetes Dimethyl sulfoxide nerve growth factor Phosphate buffered saline Substance P CSF Cerebrospinal fluid painful diabetic neuropathy protein gene product calcitonin gene related peptide