| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022528 | Neurobiology of Disease | 2012 | 12 Pages |
Abstract
⺠In this study we inactivate the mouse Tsc1 gene in dorsal neural progenitor cells. ⺠We found increased mTORC1 and decreased mTORC2 signaling in the cerebral cortex. ⺠Tsc1Emx1-Cre CKO mice have abnormalities in cortical neurons as well as glia. ⺠Tsc1Emx1-Cre CKO mice are smaller than littermates and die by postnatal day 25. ⺠Postnatal rapamycin treatment rescues mortality and reverses glial abnormalities.
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Authors
Robert P. Carson, Dominic L. Van Nielen, Peggy A. Winzenburger, Kevin C. Ess,