Mitochondrial dysfunction and accumulation of the β-secretase-cleaved C-terminal fragment of APP in Alzheimer's disease transgenic mice

► β-Cleaved C-terminal fragment of APP (C99) is targeted to mitochondria in 5XFAD mice. ► Mitochondrial C99 is primarily associated with the mitoplast in 5XFAD mice. ► BACE1+/− deletion reduces mitochondrial accumulation of C99 and fl-APP in 5XFAD mice. ► Mitochondrial targeting of C99 and fl-APP may account for mitochondrial dysfunction.