| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022537 | Neurobiology of Disease | 2012 | 13 Pages |
Abstract
⺠Abeta activates GSK3beta in cultured neurons, APP-tau mice and AD brains. ⺠Abeta exposure alters neurite morphology and inhibits CREB-target gene expression. ⺠Blocking either Abeta or GSK3beta is each sufficient to prevent this phenotype. ⺠Introduction of an uninhibitable GSK3beta produces a phenocopy in absence of Abeta. ⺠GSK3 inhibition rescues neurite changes, CREB inhibition and cognition in vivo.
Related Topics
Life Sciences
Neuroscience
Neurology
Authors
B. DaRocha-Souto, M. Coma, B.G. Pérez-Nievas, T.C. Scotton, M. Siao, P. Sánchez-Ferrer, T. Hashimoto, Z. Fan, E. Hudry, I. Barroeta, L. Serenó, M. RodrÃguez, M.B. Sánchez, B.T. Hyman, T. Gómez-Isla,