| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022540 | Neurobiology of Disease | 2012 | 12 Pages |
Abstract
⺠Ih was analyzed in non-epileptic ACI and epileptic WAG/Rij rats. ⺠Ih current density, voltage dependence, and kinetics were altered in WAG/Rij. ⺠HCN1 and the auxiliary subunit TRIP8b were stronger expressed in WAG/Rij rats. ⺠Alterations of Ih in WAG/Rij rats counteract to keep Ih availability constant. ⺠Computer simulations indicate that collectively the changes in Ih may have little impact on epileptogenesis.
Keywords
ECLventrobasal thalamic complexreticular thalamicLong Evans ratMiRP1T-type Ca2+ currentSWDNECGAERSNHSLTSdLGNaCSFPFATBSGSTGTPIgGHEPESHCNPBS1,2-Bis(o-aminophenoxy)ethane-N,N,N′,N′-tetraacetic acid4-(2-hydroxyethyl)-1-piperazineethanesulfonic acidBSAcAMPcDNAWAG/RijAdenosine TriphosphateATPCyclic adenosine monophosphatebovine serum albuminEDTAEthylenediaminetetraacetic acidcomplementary deoxyribonucleic acidSDS-PAGESodium dodecyl sulfate polyacrylamide gel electrophoresisimmunoglobulin Genhanced chemiluminescenceBAPTASpike-and-wave dischargeC-terminalTris-buffered salineELISAEnzyme-linked immunosorbent assayH-currenthyperpolarization-activated inward currentstandard error of meanFilamin Apostnatal daynormal horse serumAbsence epilepsyGenetic Absence Epilepsy Rats from StrasbourgPhosphate buffered salineartificial cerebrospinal fluidComputer modelingSEMSprague Dawley ratpolymerase chain reactionPCRparaformaldehydeacicarboxy-terminalinfrared differential interference contrastGABAglutathione-S-transferaseGuanosine triphosphate
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Authors
Tatyana Kanyshkova, Patrick Meuth, Pawan Bista, Zhiqiang Liu, Petra Ehling, Luigi Caputi, Michael Doengi, Dane M. Chetkovich, Hans-Christian Pape, Thomas Budde,