| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022553 | Neurobiology of Disease | 2012 | 8 Pages |
Abstract
⺠We generated mifepristone-inducible transgenic mouse model of OPMD ⺠Inducible expression of mutant PABPN1 resulted in skeletal and cardiac myopathy ⺠De-induction of mutant PABPN1 attenuated the myopathy and reduced PABPN1 aggregates ⺠Silencing the expression of mutant PABPN1 may be an option for therapy in OPMD
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Neuroscience
Neurology
Authors
Ami Mankodi, Thurman M. Wheeler, Reena Shetty, Kelly M. Salceies, Mark W. Becher, Charles A. Thornton,