| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022571 | Neurobiology of Disease | 2012 | 11 Pages |
Abstract
⺠Using 6-OHDA-lesioned rat, we study the role of calpains and cdk5 in dyskinesia. ⺠Intrastriatal inhibition of calpains/cdk5 activity reduces l-DOPA-induced dyskinesia. ⺠No alteration of the antiparkinsonian effect of l-DOPA is observed. ⺠These treatments reverse molecular changes associated with l-DOPA therapy. ⺠Calpains inhibition increases TH levels in the striatum of lesioned rats.
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Authors
Laure Chagniel, Christine Robitaille, Manon Lebel, Michel Cyr,