| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 6022576 | Neurobiology of Disease | 2012 | 9 Pages |
Abstract
⺠We integrate GWAS SNPs and examine the genetic control of gene expression in blood and brain tissue. ⺠Many eQTLs associated with human traits are shared between the blood and the brain. ⺠A number of discrete, tissue specific eQTLs also exist in the blood or the brain. ⺠Functional studies in blood have a limited capacity to inform on regulatory variation in the brain. ⺠Design of eQTL mapping experiments should consider the tissue of interest for the phenotype studied.
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Authors
Dena G. Hernandez, Mike A. Nalls, Matthew Moore, Sean Chong, Allissa Dillman, Daniah Trabzuni, J. Raphael Gibbs, Mina Ryten, Sampath Arepalli, Michael E. Weale, Alan B. Zonderman, Juan Troncoso, Richard O'Brien, Robert Walker, Colin Smith,