Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
6022578 | Neurobiology of Disease | 2012 | 11 Pages |
Abstract
⺠Abnormal cortex-basal ganglia synchronization and striatal hyperactivity occur in parkinsonism. ⺠We ask whether these changes are related to each other. ⺠In parkinsonism striatal hyperactivity depends on tonic activation of NMDA receptor. ⺠Cortical-pallidal low frequency synchronization is striatal NMDA receptor dependent. ⺠Whereas “beta” synchronization depends on additional mechanisms.
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Authors
Camila L. Zold, Mariela V. Escande, Pablo E. Pomata, Luis A. Riquelme, M. Gustavo Murer,